Evaluation of the Antimicrobial Effect of Pre-Synthesized Novel Antibiotic Electrospun Nanofibers as an Intracanal Delivery Strategy for Regenerative Endodontics: A Randomized Clinical Trial

AIM: The aim of this study is to evaluate the antimicrobial effect pre-synthesized novel antibiotic loaded electrospun nanofibers and compare it with conventional triple paste when used in patients immature necrotic teeth. METHODS: Antibiotic were fabricated by electrospinning. Thirty-four teeth included study. In first visit, access cavity preparation was performed obtain bacteriological sample (S1). canals thoroughly irrigated using sodium hypochlorite 1.5% a second sampling (S2). Patients randomly divided into two groups according intracanal medicament used: Modified (MTAP) or MTAP paste. At appointment, third samples (S3) taken. bacterial count determined spread plate culture technique. Scanning electron microscopy (SEM) examine morphology nanofibers. RESULTS: Both resulted significant reduction after irrigation step. significantly higher percent (p < 0.05). CONCLUSIONS: It concluded that electrospinning technology can be fabricate containing which results enhanced disinfection regenerative endodontic procedures.